Ceftriaxone-Resistant Neisseria gonorrhoeae Isolates (2010 to 2014) in France Characterized by Using Whole-Genome Sequencing
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| Titre | Ceftriaxone-Resistant Neisseria gonorrhoeae Isolates (2010 to 2014) in France Characterized by Using Whole-Genome Sequencing |
| Type de publication | Journal Article |
| Year of Publication | 2016 |
| Auteurs | de Curraize C, Kumanski S, Micaelo M, Fournet N, La Ruche G, Meunier F, Amarsy R, Jacquier H, Cambau E, Goubard A, Bercot B |
| Journal | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY |
| Volume | 60 |
| Pagination | 6962-6964 |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 0066-4804 |
| Résumé | Two extended-spectrum cephalosporin-resistant Neisseria gonorrhoeae isolates were discovered among 6,340 (0.03%) French isolates between 2010 and 2014. One isolate corresponded to the F89 multidrug-resistant N. gonorrhoeae isolate harboring a penA mosaic; whole-genome sequencing highlighted an additional R251H substitution in the ftsX gene recently involved in cephalosporin resistance. The other, ceftriaxone-resistant isolate ( MIC, 0.25 mg/liter) harbored the PBP2 pattern XXXVI plus a P551S substitution and belonged to sequence type ST1579 (multilocus sequence typing [MLST]). |
| DOI | 10.1128/AAC.01568-16 |