MRI and serum biomarkers correlate with radiographic features in painful hand osteoarthritis

Affiliation auteurs!!!! Error affiliation !!!!
TitreMRI and serum biomarkers correlate with radiographic features in painful hand osteoarthritis
Type de publicationJournal Article
Year of Publication2016
AuteursRoux C.H, Foltz V., Maheu E., Baron G., Gandjbakhch F., Lukas C., Wendling D., Loeuille D., Lafforgue P., Euller-Ziegler L., Richette P., Chevalier X., Osteoarthritis FSect
JournalCLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Volume34
Pagination991-998
Date PublishedNOV-DEC
Type of ArticleArticle
ISSN0392-856X
Mots-clésbiologic markers, hand osteoarthritis, mri, Radiology
Résumé

{Objective To explore the relationship between clinical findings, biologic biomarkers, conventional radiography and MRI in patients with painful hand OA. Methods The following patient baseline data from the DORA study (evaluating anti-TNF-alpha agents against painful hand OA) were used: clinical assessment (pain, swelling, stiffness and function: Dreiser functional hand index [FIHOA] and Cochin hand functional scale [CHFS]); measurement of biomarkers (cartilage oligomeric matrix protein (COMP), type IIA collagen N-propeptid (PIINP), hyaluronic acid (HA), ultrasensitive C-reactive protein (usCRP), tumour necrosis factor (TNF), interleukin (IL)-6, IL-1 beta and urinary CTXII); radiological staging (Verbruggen, Kallman, Kellgren-Lawrence); anatomical evaluation by contrast-enhanced MRI of proximal and distal interphalangeal joints of dominant hand. Associations between clinical, biomarker and imaging findings were assessed using the Spearman correlation coefficient and test. Results 18 patients were recruited, and 144 joints studied. A correlation was found between clinical features (pain, FIHOA, CHFS) and the Verbruggen score (respectively: p=0.05