Effects of anti-TNF-alpha agents on circulating endothelial-derived and platelet-derived microparticles in psoriasis
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Effects of anti-TNF-alpha agents on circulating endothelial-derived and platelet-derived microparticles in psoriasis |
| Type de publication | Journal Article |
| Year of Publication | 2014 |
| Auteurs | Pelletier F, Garnache-Ottou F, Biichle S, Vivot A, Humbert P, Saas P, Seilles E, Aubin F |
| Journal | EXPERIMENTAL DERMATOLOGY |
| Volume | 23 |
| Pagination | 924-925 |
| Date Published | DEC |
| Type of Article | Article |
| ISSN | 0906-6705 |
| Mots-clés | anti-TNF- agents, endothelial microparticles, platelet microparticles, Psoriasis |
| Résumé | {Psoriasis involves TNF- secretion leading to release of microparticles into the bloodstream. We investigated the effect of TNF blockers on microparticles levels before and after treatment in patients (twenty treated by anti-TNF- agents and 6 by methotrexate) with severe psoriasis. Plasmatic microparticles were labelled using fluorescent monoclonal antibodies and were analysed using cytometry. Three months later, 70% of patients treated with anti-TNF- agents achieved a reduction in PASI score of at least 75%. The clinical improvement in patients treated with anti-TNF- agents was associated with a significant reduction of the mean number of platelet microparticles (2837/l vs 1849/l |
| DOI | 10.1111/exd.12551 |