The health and economic burden of bloodstream infections caused by antimicrobial-susceptible and non-susceptible Enterobacteriaceae and Staphylococcus aureus in European hospitals, 2010 and 2011: a multicentre retrospective cohort study

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TitreThe health and economic burden of bloodstream infections caused by antimicrobial-susceptible and non-susceptible Enterobacteriaceae and Staphylococcus aureus in European hospitals, 2010 and 2011: a multicentre retrospective cohort study
Type de publicationJournal Article
Year of Publication2016
AuteursStewardson A.J, Allignol A., Beyersmann J., Graves N., Schumacher M., Meyer R., Tacconelli E., De Angelis G., Farina C., Pezzoli F., Bertrand X., Gbaguidi-Haore H., Edgeworth J., Tosas O., Martinez J.A, Ayala-Blanco M.P, Pan A., Zoncada A., Marwick C.A, Nathwani D., Seifert H., Hos N., Hagel S., Pletz M., Harbarth S., Grp TIMBERStudy
JournalEUROSURVEILLANCE
Volume21
Pagination30319
Date PublishedAUG 18
Type of ArticleArticle
ISSN1560-7917
Résumé

{We performed a multicentre retrospective cohort study including 606,649 acute inpatient episodes at 10 European hospitals in 2010 and 2011 to estimate the impact of antimicrobial resistance on hospital mortality, excess length of stay (LOS) and cost. Bloodstream infections (BSI) caused by third-generation cephalosporin- resistant Enterobacteriaceae (3GCRE), meticillin-susceptible (MSSA) and - resistant Staphylococcus aureus (MRSA) increased the daily risk of hospital death (adjusted hazard ratio (HR) = 1.80; 95% confidence interval (CI): 1.34-2.42
DOI10.2807/1560-7917.ES.2016.21.33.30319