Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease |
| Type de publication | Journal Article |
| Year of Publication | 2016 |
| Auteurs | Schott JM, Crutch SJ, Carrasquillo MM, Uphill J, Shakespeare TJ, Ryan NS, Yong KX, Lehmann M, Ertekin-Taner N, Graff-Radford NR, Boeve BF, Murray ME, Khan Qul Ain, Petersen RC, Dickson DW, Knopman DS, Rabinovici GD, Miller BL, Gonzalez ASuarez, Gil-Neciga E, Snowden JS, Harris J, Pickering-Brown SM, Louwersheimer E, van der Flier WM, Scheltens P, Pijnenburg YA, Galasko D, Sarazin M, Dubois B, Magnin E, Galimberti D, Scarpini E, Cappa SF, Hodges JR, Halliday GM, Bartley L, Carrillo MC, Brass JT, Hardy J, Rossor MN, Collinge J, Fox NC, Mead S |
| Journal | ALZHEIMERS & DEMENTIA |
| Volume | 12 |
| Pagination | 862-871 |
| Date Published | AUG |
| Type of Article | Article |
| ISSN | 1552-5260 |
| Mots-clés | Alzheimer's disease, ApoE, genetics, GWAS, posterior cortical atrophy, Selective vulnerability |
| Résumé | {Introduction: The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain. Methods: We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association study. Results: We confirm that variation in/near APOE/TOMM40 (P = 6 X 10(-14)) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] = 2.03, typical AD: OR = 2.83 |
| DOI | 10.1016/j.jalz.2016.01.010 |