The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein

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TitreThe metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein
Type de publicationJournal Article
Year of Publication2016
AuteursRamos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G, Sboner A, Zhang T, Xiang J, Merghoub T, Levin LR, Buck J, Zippin JH
JournalONCOTARGET
Volume7
Pagination45597-45607
Date PublishedJUL 19
Type of ArticleArticle
Mots-cléscAMP, metabolic sensor, Microdomain, sAC, tumor suppressor
Résumé

cAMP signaling pathways can both stimulate and inhibit the development of cancer; however, the sources of cAMP important for tumorigenesis remain poorly understood. Soluble adenylyl cyclase (sAC) is a non-canonical, evolutionarily conserved, nutrient-and pH-sensing source of cAMP. sAC has been implicated in the metastatic potential of certain cancers, and it is differentially localized in human cancers as compared to benign tissues. We now show that sAC expression is reduced in many human cancers. Loss of sAC increases cellular transformation in vitro and malignant progression in vivo. These data identify the metabolic/pH sensor soluble adenylyl cyclase as a previously unappreciated tumor suppressor protein.

DOI10.18632/oncotarget.10056