The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein
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Titre | The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein |
Type de publication | Journal Article |
Year of Publication | 2016 |
Auteurs | Ramos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G, Sboner A, Zhang T, Xiang J, Merghoub T, Levin LR, Buck J, Zippin JH |
Journal | ONCOTARGET |
Volume | 7 |
Pagination | 45597-45607 |
Date Published | JUL 19 |
Type of Article | Article |
Mots-clés | cAMP, metabolic sensor, Microdomain, sAC, tumor suppressor |
Résumé | cAMP signaling pathways can both stimulate and inhibit the development of cancer; however, the sources of cAMP important for tumorigenesis remain poorly understood. Soluble adenylyl cyclase (sAC) is a non-canonical, evolutionarily conserved, nutrient-and pH-sensing source of cAMP. sAC has been implicated in the metastatic potential of certain cancers, and it is differentially localized in human cancers as compared to benign tissues. We now show that sAC expression is reduced in many human cancers. Loss of sAC increases cellular transformation in vitro and malignant progression in vivo. These data identify the metabolic/pH sensor soluble adenylyl cyclase as a previously unappreciated tumor suppressor protein. |
DOI | 10.18632/oncotarget.10056 |