B Cells and Antibodies in Transplantation

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TitreB Cells and Antibodies in Transplantation
Type de publicationJournal Article
Year of Publication2016
AuteursKoenig A, Mariat C, Mousson C, Wood KJ, Rifle G, Thaunat O
JournalTRANSPLANTATION
Volume100
Pagination1460-1464
Date PublishedJUL
Type of ArticleReview
ISSN0041-1337
Résumé

Overlooked for decades, the humoral alloimmune response is increasingly recognized as a leading cause of graft loss after transplantation. However, improvement in the diagnosis of antibody-mediated rejection has not yet translated into better outcomes for transplanted patients. After an update on B cell physiology and antibody generation, the 2015 Beaune Seminar in Transplant Research challenged the conventional view of antibody-mediated rejection pathophysiology and discussed the latest promising therapeutic approaches.

DOI10.1097/TP.0000000000001069