Pre-transplant end-stage renal disease-related immune risk profile in kidney transplant recipients predicts post-transplant infections
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Pre-transplant end-stage renal disease-related immune risk profile in kidney transplant recipients predicts post-transplant infections |
| Type de publication | Journal Article |
| Year of Publication | 2016 |
| Auteurs | Crepin T., Gaiffe E., Courivaud C., Roubiou C., Laheurte C., Moulin B., Frimat L., Rieu P., Mousson C., Durrbach A., Heng A.-E, Saas P., Bamoulid J., Ducloux D. |
| Journal | TRANSPLANT INFECTIOUS DISEASE |
| Volume | 18 |
| Pagination | 415-422 |
| Date Published | JUN |
| Type of Article | Article |
| ISSN | 1398-2273 |
| Mots-clés | CMV, immune risk phenotype, immune senescence, Infection, transplantation |
| Résumé | {BackgroundEnd-stage renal disease (ESRD) is associated with premature aging of the T-cell system. Nevertheless, the clinical significance of pre-transplant ESRD-related immune senescence is unknown. MethodsWe studied whether immune risk phenotype (IRP), a typical feature of immune senescence, may affect post-transplant infectious complications. A total of 486 patients were prospectively studied during the first year post transplant. IRP was defined as positive cytomegalovirus serology with at least 1 of the following criteria: CD4/CD8 ratio <1 and/or CD8 T-cell count >90th percentile. ResultsWe found that 47 patients (9.7%) had pre-transplant IRP. IRP+ patients did not differ from IRP- patients for any clinical characteristics, but exhibited more pronounced immune senescence. Both opportunistic infections (43% vs. 6%, P < 0.001) and severe bacterial infection (SBI) (40% vs. 25% |
| DOI | 10.1111/tid.12534 |