Multicenter Comparison of the Etest and EUCAST Methods for Antifungal Susceptibility Testing of Candida Isolates to Micafungin

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TitreMulticenter Comparison of the Etest and EUCAST Methods for Antifungal Susceptibility Testing of Candida Isolates to Micafungin
Type de publicationJournal Article
Year of Publication2016
AuteursBougnoux M.-E, Dannaoui E., Accoceberry I., Angoulvant A., Bailly E., Botterel F., Chevrier S., Chouaki T., Cornet M., Dalle F., Datry A., Dupuis A., Fekkar A., Gangneux J.P, Guitard J., Hennequin C., Le Govic Y., Le Pape P., Maubon D., Ranque S., Sautour M., Sendid B., Chandenier J.
JournalANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume60
Pagination5088-5091
Date PublishedAUG
Type of ArticleArticle
ISSN0066-4804
Résumé

In vitro susceptibility of 933 Candida isolates, from 16 French hospitals, to micafungin was determined using the Etest in each center. All isolates were then sent to a single center for determination of MICs by the EUCAST reference method. Overall essential agreement between the two tests was 98.5% at +/- 2 log(2) dilutions and 90.2% at +/- 1 log(2) dilutions. Categorical agreement was 98.2%. The Etest is a valuable alternative to EUCAST for the routine determination of micafungin MICs in medical mycology laboratories.

DOI10.1128/AAC.00630-16