Transcranial direct current stimulation for acute major depressive episodes: meta-analysis of individual patient data

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TitreTranscranial direct current stimulation for acute major depressive episodes: meta-analysis of individual patient data
Type de publicationJournal Article
Year of Publication2016
AuteursBrunoni AR, Moffa AH, Fregni F, Palm U, Padberg F, Blumberger DM, Daskalakis ZJ, Bennabi D, Haffen E, Alonzo A, Loo CK
JournalBRITISH JOURNAL OF PSYCHIATRY
Volume208
Pagination522+
Date PublishedJUN
Type of ArticleReview
ISSN0007-1250
Résumé

{Background Transcranial direct current stimulation (tDCS) is a non-pharmacological intervention for depression. It has mixed results, possibly caused by study heterogeneity. Aims To assess tDCS efficacy and to explore individual response predictors. Method Systematic review and individual patient data meta-analysis. Results Data were gathered from six randomised sham-controlled trials, enrolling 289 patients. Active tDCS was significantly superior to sham for response (34% v. 19% respectively, odds ratio (OR) = 2.44, 95% CI 1.38-4.32, number needed to treat (NNT) = 7), remission (23.1% v. 12.7% respectively

DOI10.1192/bjp.bp.115.164715