Impact of clinical and genetic findings on the management of young patients with Brugada syndrome
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Impact of clinical and genetic findings on the management of young patients with Brugada syndrome |
| Type de publication | Journal Article |
| Year of Publication | 2016 |
| Auteurs | Andorin A, Behr ER, Denjoy I, Crotti L, Dagradi F, Jesel L, Sacher F, Petit B, Mabo P, Maltret A, Wong LCH, Degand B, Bertaux G, Maury P, Dulac Y, Delasalle B, Gourraud J-B, Babuty D, Blom NA, Schwartz PJ, Wilde AA, Probst V |
| Journal | HEART RHYTHM |
| Volume | 13 |
| Pagination | 1274-1282 |
| Date Published | JUN |
| Type of Article | Article |
| ISSN | 1547-5271 |
| Mots-clés | arrhythmia, Brugada syndrome, genetics, Pediatrics, Quinidine |
| Résumé | {BACKGROUND Brugada syndrome (BrS) is an arrhythmogenic disease associated with sudden cardiac death (SCD) that seldom manifests or is recognized in childhood. OBJECTIVES The objectives of this study were to describe the clinical presentation of pediatric BrS to identify prognostic factors for risk stratification and to propose a data-based approach management. METHODS We studied 106 patients younger than 19 years at diagnosis of BrS enrolled from 16 European hospitals. RESULTS At diagnosis, BrS was spontaneous (n = 36, 34%) or drug-induced (n = 70, 66%). The mean age was 11.1 +/- 5.7 years, and most patients were asymptomatic (family screening, (n = 67, 63%; incidental |
| DOI | 10.1016/j.hrthm.2016.02.013 |