A phenotypic and mechanistic perspective on heterogeneity of HER2-positive breast cancers
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | A phenotypic and mechanistic perspective on heterogeneity of HER2-positive breast cancers |
| Type de publication | Journal Article |
| Year of Publication | 2016 |
| Auteurs | Ferrari A, Sertier A-S, Vincent-Salomon A, Pivot X, Pauporte I, Saintigny P, Birnbaum D, Viari A |
| Journal | MOLECULAR & CELLULAR ONCOLOGY |
| Volume | 3 |
| Pagination | UNSP e1232186 |
| Type of Article | Article |
| Mots-clés | Breakage-Fusion-Bridge, Breast cancer, cancer genomics, ERBB2 amplification, mammary epithelial hierarchy |
| Résumé | Analysis of gene expression and whole-genome features of 64 human epidermal growth factor 2 (HER2)positive breast tumors supports the idea that their intrinsic heterogeneity actually reflects their cell of origin, suggesting that HER2 amplification is an embedded event in the natural history of these tumors. Possible mechanisms for this event involve breakage-fusion-bridge and chromothripsis. |
| DOI | 10.1080/23723556.2016.1232186 |