Relationships of Macular Pigment Optical Density With Plasma Lutein, Zeaxanthin, and Diet in an Elderly Population: The Montrachet Study
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| Titre | Relationships of Macular Pigment Optical Density With Plasma Lutein, Zeaxanthin, and Diet in an Elderly Population: The Montrachet Study |
| Type de publication | Journal Article |
| Year of Publication | 2016 |
| Auteurs | Alassane S, Binquet C, Cottet V, Fleck O, Acar N, Daniel S, Delcourt C, Bretillon L, Bron AM, Creuzot-Garcher C |
| Journal | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE |
| Volume | 57 |
| Pagination | 1160-1167 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 0146-0404 |
| Mots-clés | Diet, Elderly, lutein, macular pigment optical density, Population-based study, zeaxanthin |
| Résumé | {PURPOSE. To investigate the association of macular pigment optical density (MPOD) with plasma lutein, zeaxanthin, and diet in an elderly population. METHODS. We conducted a population-based study, the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease) study, in subjects older than 75 years. The MPOD was measured by means of the two-wavelength autofluorescence technique. Plasma lutein and zeaxanthin were measured in fasting blood samples using HPLC. Food frequency consumption was assessed with self-reported food frequency questionnaires. RESULTS. Overall, 433 healthy participants (62.1% females) were included. Mean age was 82.0 +/- 3.6 years. Mean MPOD at 0.5 degrees eccentricity was 0.57 +/- 0.25 density units (DU) and was higher in women than in men (0.59 +/- 0.25 vs. 0.53 +/- 0.25 |
| DOI | 10.1167/iovs.15-18007 |