Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

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TitrePlasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Type de publicationJournal Article
Year of Publication2014
AuteursNitter M., Norgard B., de Vogel S., Eussen S.JPM, Meyer K., Ulvik A., Ueland P.M, Nygard O., Vollset S.E, Bjorge T., Tjonneland A., Hansen L., Boutron-Ruault M., Racine A., Cottet V., Kaaks R., Kuehn T., Trichopoulou A., Bamia C., Naska A., Grioni S., Palli D., Panico S., Tumino R., Vineis P., Bueno-de-Mesquita H.B, van Kranen H., Peeters P.H, Weiderpass E., Dorronsoro M., Jakszyn P., Sanchez M., Argueelles M., Huerta J.M, Barricarte A., Johansson M., Ljuslinder I., Khaw K., Wareham N., Freisling H., Duarte-Salles T., Stepien M., Gunter M.J, Riboli E.
JournalANNALS OF ONCOLOGY
Volume25
Pagination1609-1615
Date PublishedAUG
Type of ArticleArticle
ISSN0923-7534
Mots-clésbetaine, choline, colorectal cancer risk, dimethylglycine, methionine, population-based case-control study
Résumé

{Background: Disturbances in one carbon metabolism may contribute to carcinogenesis by affecting methylation and synthesis of DNA. Choline and its oxidation product betaine are involved in this metabolism and can serve as alternative methyl group donors when folate status is low. Patients and methods: We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), to investigate plasma concentrations of the methyl donors methionine, choline, betaine (trimethylglycine), and dimethylglycine (DMG) in relation to colorectal cancer (CRC) risk. Our study included 1367 incident CRC cases (965 colon and 402 rectum) and 2323 controls matched by gender, age group, and study center. Multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for CRC risk were estimated by conditional logistic regression, comparing the fifth to the first quintile of plasma concentrations. Results: Overall, methionine (OR: 0.79, 95% CI: 0.63-0.99
DOI10.1093/annonc/mdu185