Effect of magnesium, probiotic, and vitamin food supplementation in healthy subjects with psychological stress and evaluation of a persistent effect after discontinuing intake

BACKGROUND: The aim of this paper was to describe the changes in subjects' psychological stress intensity under the effect of dietary supplements of magnesium, probiotics, and vitamins after one month of intake. METHODS: Observational cohort study of subject complaining of psychological stress defined by a Perceived Stress Scale (PSS 10) score of more than 21. RESULTS: The study covered 242 healthy volunteers, 38.6+/-13.6-year-old, among whom 79.8% were women. Under the effect of the supplementation of magnesium, probiotics, and vitamins, the psychological stress of the subjects decreased significantly from 34.1+/-4.5 to 26.2+/-16.1 (P<0.0001), which corresponds to an average reduction of 22.7+/-16.0%. Fatigue decreased even more significantly from 16.8+/-6.4 to 8.7+/-6.2 (P<0.0001), which corresponds to an average reduction of 45.0%+/-38.1%. Analysis showed that the psychological stress level was strictly similar one month after the treatment was discontinued and therefore clearly demonstrated that the psychological benefit was maintained over time. CONCLUSIONS: Stress and fatigue are significantly reduced by the intake of a food supplement with probiotics, magnesium, vitamins, and minerals and this effect is fully maintained one month after discontinuing the food supplement intake.