Efficacy and safety of tumor necrosis factor antagonists in refractory sarcoidosis: A multicenter study of 132 patients

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TitreEfficacy and safety of tumor necrosis factor antagonists in refractory sarcoidosis: A multicenter study of 132 patients
Type de publicationJournal Article
Year of Publication2017
AuteursJamilloux Y, Cohen-Aubart F, Chapelon-Abric C, Maucort-Boulch D, Marquet A, Perard L, Bouillet L, Deroux A, Abad S, Bielefeld P, Bouvry D, Andre M, Noel N, Bienvenu B, Proux A, Vukusic S, Bodaghi B, Sarrot-Reynauld F, Iwaz J, Amoura Z, Broussolle C, Cacoub P, Saadoun D, Valeyre D, Seve P, Francophone GSarcoidose
JournalSEMINARS IN ARTHRITIS AND RHEUMATISM
Volume47
Pagination288-294
Date PublishedOCT
Type of ArticleReview
ISSN0049-0172
Mots-clésEfficacy, Safety, sarcoidosis, TNF antagonist
Résumé

Introduction: The off-label use of TNF antagonists in refractory sarcoidosis is increasingly reported but data on their efficacy and safety are still insufficient. Objective: To report on efficacy and safety of TNF antagonists in severe and refractory sarcoidosis. Methods: Examination of retrospective demographic, clinical, therapeutic, and adverse event data on 132 sarcoidosis patients (58% women; mean (min-max) age = 45.5 (14-78) years) given TNF antagonists (mainly infliximab, 91%) and investigation of response-linked factors. Results: The overall clinical response (complete and partial) rate was 64%. TNF-antagonist efficacy (i.e., significant decrease of the ePOST score) was noted in cases with neurologic, heart, skin, and upper respiratory tract involvements. No significant difference in efficacy was found between anti-TNF used alone and TNF with immunosuppressant. The use of anti-TNF allowed reducing prednisone dosage at end of follow-up (p < 0.001). Adverse events were observed in 52% of the patients; they included infections (36%) and allergic reactions (8%) and required treatment interruption in 31 cases (23%). When TNF antagonists were interrupted, 13 patients experienced relapses within 14 months on average (median follow-up: 20.5 months). Conclusion: TNF antagonists were efficacious in about two-thirds of patients with severe/refractory sarcoidosis but their use led to a high rate of adverse events. (C) 2017 Elsevier Inc. All rights reserved.

DOI10.1016/j.semarthrit.2017.03.005