Impact of completion axillary lymph node dissection in patients with breast cancer and isolated tumour cells or micrometastases in sentinel nodes
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Impact of completion axillary lymph node dissection in patients with breast cancer and isolated tumour cells or micrometastases in sentinel nodes |
| Type de publication | Journal Article |
| Year of Publication | 2016 |
| Auteurs | Houvenaeghel G., Boher J.M, Reyal F., Cohen M., Garbay J.R, Classe J.M, Rouzier R., Giard S., Faure C., Charitansky H., C. de Lara T, Darai E., Hudry D., Azuar P., Gimbergues P., Villet R., Sfumato P., Lambaudie E. |
| Journal | EUROPEAN JOURNAL OF CANCER |
| Volume | 67 |
| Pagination | 106-118 |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 0959-8049 |
| Mots-clés | Axillary lymph node dissection, Breast cancer, Isolated tumour cells, micrometastases, sentinel node |
| Résumé | {Background: Omission of completion axillary lymph node dissection (ALND) is a standard practice in patients with breast cancer (BC) and negative sentinel nodes (SNs) but has shown insufficient evidence to be recommended in those with SN invasion. Methods: A retrospective analysis of a cohort of patients with BC and micrometastases (Mic) or isolated tumour cells (ITCs) in SN. Factors associated with ALND were identified, and patients with ALND were matched to patients without ALND. Overall survival (OS) and recurrence-free survival (RFS) were estimated in the overall population, in Mic and in ITC cohorts. Findings: Among 2009 patients analysed, 1390 and 619 had Mic and ITC in SN, respectively. Factors significantly associated with ALND were SN status, histological type, age, number of SN harvested and absence of adjuvant chemotherapy. After a median follow-up of 60.4 months, ALND omission was independently associated with reduced OS (hazard ratio [HR] 2.41, 90 confidence interval [CI] 1.36-4.27 |
| DOI | 10.1016/j.ejca.2016.08.003 |