Islet of Langerhans isolation from pediatric and juvenile donor pancreases
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Islet of Langerhans isolation from pediatric and juvenile donor pancreases |
| Type de publication | Journal Article |
| Year of Publication | 2014 |
| Auteurs | Meier RPH, Sert I, Morel P, Muller YD, Borot S, Badet L, Toso C, Bosco D, Berney T |
| Journal | TRANSPLANT INTERNATIONAL |
| Volume | 27 |
| Pagination | 949-955 |
| Date Published | SEP |
| Type of Article | Article |
| ISSN | 0934-0874 |
| Mots-clés | islet isolation, islet transplantation, type 1 diabetes mellitus, young donors |
| Résumé | {Islet grafts isolated from young donors allow superior functional outcomes but are often associated with poor islet isolation yields. The objective of this study was to comparatively analyze the outcomes of islet isolation between young and older donors. We retrospectively analyzed 564 pancreas isolations performed at our institution. Isolation outcomes were compared between donors aged <= 20 years (n = 42, YD) and >20 years (n = 522, OD). Isolation procedure was identical in both groups. Prepurification percentage of embedded islets was higher in YD (44.3 +/- 22.7% vs. 24.9 +/- 20.9%, P < 0.001). This led to a lower recovery rate in YD (48% vs. 76% |
| DOI | 10.1111/tri.12367 |