Gold(I)-Coumarin-Caffeine-Based Complexes as New Potential Anti-Inflammatory and Anticancer Trackable Agents
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Gold(I)-Coumarin-Caffeine-Based Complexes as New Potential Anti-Inflammatory and Anticancer Trackable Agents |
| Type de publication | Journal Article |
| Year of Publication | 2018 |
| Auteurs | Trommenschlager A, Chotard F, Bertrand B, Amor S, Richard P, Bettaieb A, Paul C, Connat J-L, Le Gendre P, Bodio E |
| Journal | CHEMMEDCHEM |
| Volume | 13 |
| Pagination | 2408-2414 |
| Date Published | NOV 20 |
| Type of Article | Article |
| ISSN | 1860-7179 |
| Mots-clés | antiproliferation, Bioinorganic Chemistry, Cancer, Gold, theranostics |
| Résumé | Three new gold(I)-coumarin-based trackable therapeutic complexes and two non-trackable analogues have been synthesised and fully characterised. They all display anti-proliferative properties on several types of cancer cell lines, including those of colon, breast, and prostate. Two complexes displayed significant anti-inflammatory effects; one displayed pro-inflammatory behaviour; this highlights the impact of the position of the fluorophore on the caffeine scaffold. Additionally, the three coumarin derivatives could be visualised in vitro by two-photon microscopy. |
| DOI | 10.1002/cmdc.201800474 |