Mitophagy mechanisms and role in human diseases
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Mitophagy mechanisms and role in human diseases |
| Type de publication | Journal Article |
| Year of Publication | 2014 |
| Auteurs | Redmann M, Dodson M, Boyer-Guittaut M, Darley-Usmar V, Zhang J |
| Journal | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY |
| Volume | 53 |
| Pagination | 127-133 |
| Date Published | AUG |
| Type of Article | Article |
| ISSN | 1357-2725 |
| Mots-clés | Cancer, Heart disease, Mitochondria, Mitophagy, Parkinson's disease |
| Résumé | Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy activities. This review will highlight recent studies that have identified mediators of mitophagy in response to starvation, loss of mitochondrial membrane potential or perturbation of mitochondrial integrity. Furthermore, we will review evidence of mitophagy dysfunction in various human diseases and discuss the potential for therapeutic interventions that target mitophagy processes. (C) 2014 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.biocel.2014.05.010 |