Phytochemistry of Weigela x ``kosteriana variegata'' (Caprifoliaceae)

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TitrePhytochemistry of Weigela x ``kosteriana variegata'' (Caprifoliaceae)
Type de publicationJournal Article
Year of Publication2018
AuteursAndriamisaina N, Mitaine-Offer A-C, Pruvot B, Chluba J, Miyamoto T, Tanaka C, Lacaille-Dubois M-A
JournalNATURAL PRODUCT COMMUNICATIONS
Volume13
Pagination403-406
Date PublishedAPR
Type of ArticleArticle
ISSN1934-578X
Mots-clés2D NMR, Caprifoliaceae, Oleanolic acid glycosides, Weigela x ``kosteriana variegata'', Zebrafish-based assay
Résumé

One new triterpene glycoside 3-O-beta-D-xylopyranosyl-(1 -> 4)-[beta-D-glucopyranosyl-(1 -> 3)]-beta-D-xyl opyranosyl-(1 -> 4)-beta-D-xylopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyloleanolic acid, was isolated from Weigela x ``kosteriana variegata'' (Caprifoliaceae), with three known ones. Their structures were characterized by a combination of mass spectrometry and 1D and 2D NMR spectrocopic techniques including H-1- and C-13 NMR, COSY, TOCSY, NOESY, HSQC, and HMBC experiments. The toxicological properties of some glycosides were determined with a zebrafish-based assay. The results show that the most active compounds were toxic to the larvae in the range of 1 mu M.