Azole-Resistant Aspergillus fumigatus Isolate with the TR34/L98H Mutation in Both a Fungicide-Sprayed Field and the Lung of a Hematopoietic Stem Cell Transplant Recipient with Invasive Aspergillosis

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TitreAzole-Resistant Aspergillus fumigatus Isolate with the TR34/L98H Mutation in Both a Fungicide-Sprayed Field and the Lung of a Hematopoietic Stem Cell Transplant Recipient with Invasive Aspergillosis
Type de publicationJournal Article
Year of Publication2014
AuteursRocchi S, Daguindau E, Grenouillet F, Deconinck E, Bellanger A-P, Garcia-Hermoso D, Bretagne S, Reboux G, Millon L
JournalJOURNAL OF CLINICAL MICROBIOLOGY
Volume52
Pagination1724-1726
Date PublishedMAY
Type of ArticleArticle
ISSN0095-1137
Résumé

A French farmer developed invasive aspergillosis with azole-resistant Aspergillus fumigatus with the TR34/L98H mutation following a hematopoietic stem cell transplantation. He had worked in fungicide-sprayed fields where a non-genetically related A. fumigatus TR34/L98H isolate was collected. If azole resistance detection increases, voriconazole as first-line therapy might be questioned in agricultural areas.

DOI10.1128/JCM.03182-13