Real-Time Observation of ``Soft'' Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate

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TitreReal-Time Observation of ``Soft'' Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate
Type de publicationJournal Article
Year of Publication2021
AuteursSzczerba D, Tan D, Do J-L, Titi HM, Mouhtadi S, Chaumont D, de Lucas Mdel Carmen, Geoffroy N, Meyer M, Rousselin Y, Hudspeth JM, Schwanen V, Spoerk-Erdely P, Dippel A-C, Ivashko O, Gutowski O, Glaevecke P, Bazhenov V, Arhangelskis M, Halasz I, Friscic T, Kimber SAJ
JournalJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume143
Pagination16332-16336
Date PublishedOCT 13
Type of ArticleArticle
ISSN0002-7863
Résumé

Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such ``magic-size'' clusters can be both stable enough to crystallize and sufficiently labile for further growth.

DOI10.1021/jacs.1c07186