Real-Time Observation of ``Soft'' Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate
Affiliation auteurs | !!!! Error affiliation !!!! |
Titre | Real-Time Observation of ``Soft'' Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate |
Type de publication | Journal Article |
Year of Publication | 2021 |
Auteurs | Szczerba D, Tan D, Do J-L, Titi HM, Mouhtadi S, Chaumont D, de Lucas Mdel Carmen, Geoffroy N, Meyer M, Rousselin Y, Hudspeth JM, Schwanen V, Spoerk-Erdely P, Dippel A-C, Ivashko O, Gutowski O, Glaevecke P, Bazhenov V, Arhangelskis M, Halasz I, Friscic T, Kimber SAJ |
Journal | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY |
Volume | 143 |
Pagination | 16332-16336 |
Date Published | OCT 13 |
Type of Article | Article |
ISSN | 0002-7863 |
Résumé | Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such ``magic-size'' clusters can be both stable enough to crystallize and sufficiently labile for further growth. |
DOI | 10.1021/jacs.1c07186 |