Epigenetic Reprogramming of CD4(+) Helper T Cells as a Strategy to Improve Anticancer Immunotherapy

Evidences highlight the role of various CD4(+) helper T cells (CD4(+) Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4(+) Th polarization and plasticity. In this review, we described the epigenetic factors that govern CD4(+) T cells differentiation and recruitment in the tumor microenvironment and their subsequent involvement in the antitumor immunity. Finally, we discussed how to manipulate tumor reactive CD4(+) Th responses by epigenetic drugs to improve anticancer immunotherapy.