Targeted therapies and diabetes

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TitreTargeted therapies and diabetes
Type de publicationJournal Article
Year of Publication2017
AuteursVerges B
JournalCORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION
Volume21
Pagination66-69
Date PublishedMAR-APR
Type of ArticleArticle
ISSN2100-9619
Mots-clésdiabetes, mTOR inhibitor, Targeted therapy, Tyrosine kinase inhibitor
Résumé

mTOR inhibitors, which are important anti-cancer agents, may frequently induce hyperglycemias in 13% to 50% of the patients. Diabetes induced by mTOR inhibitors seems to be due to both insulin resistance and reduced insulin secretion. Because of the high risk of diabetes with mTOR inhibitors, blood glucose needs to be carefully monitored during treatment. Tyrosine kinase inhibitors may induce both hyperglycemias and hypoglycemias