Crystal structures of two polymorphs of tixocortol pivalate

Two polymorphs, (I) and (II), of (S)-{2-[(8S,9S,10R,11S,13S,14S,17R)-11,17dihydroxy-10,13- dimethyl- 3- oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[ a]phenanthren-17-yl]-2-oxoethyl} 2,2- dimethylpropanethioate, C26H38O5S, have been identified. They are orthorhombic, non-centrosymmetric (P(2)1(2)1(2)1). The structures display layers of molecules conected via O-H center dot center dot center dot O hydrogen bonds along the b-axis direction in polymorph (I) and along the c-axis direction in polymorph (II). The structure of ( II) exhibits disorder of the main molecule.