Human papillomavirus DNA and p16 expression in head and neck squamous cell carcinoma in young French patients

Affiliation auteurs!!!! Error affiliation !!!!
TitreHuman papillomavirus DNA and p16 expression in head and neck squamous cell carcinoma in young French patients
Type de publicationJournal Article
Year of Publication2021
AuteursMolimard C, L'Huillier V, Overs A, Soret C, Algros M-P, Mougin C, Guenat D, Mauvais O, Pretet J-L
JournalJOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume49
Pagination03000605211022534
Date PublishedJUL
Type of ArticleArticle
ISSN0300-0605
Mots-clésbiomarker, Head and neck squamous cell carcinoma, Human papillomavirus, p16 expression, virus DNA, young patient
Résumé

Objectives Human papillomavirus (HPV) is a risk factor for head and neck squamous cell carcinoma (HNSCC), which is currently increasing worldwide. We evaluated the prevalence of HPV DNA and p16 expression in HNSCC patients age Methods Thirty-nine patients aged Results The overall prevalence of HPV infection was 11.7%. HPV16 was the only genotype detected in 4/39 and 5/38 patients, and p16 was expressed in 6/39 and 4/38 patients aged <45 years and >= 45 years, respectively. Conclusions HPV-positivity and p16 expression were similar in both age groups. The results suggest that p16 immunohistochemistry may provide a prognosis biomarker for all HNSCCs, not only oropharyngeal cancers, and this should be addressed in large clinical trials.
DOI10.1177/03000605211022534