Inflammatory and immunological profile in COPD secondary to organic dust exposure

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TitreInflammatory and immunological profile in COPD secondary to organic dust exposure
Type de publicationJournal Article
Year of Publication2021
AuteursKeddache S, Laheurte C, Boullerot L, Laurent L, Dalphin J-C, Adotevi O, Soumagne T
JournalCLINICAL IMMUNOLOGY
Volume229
Pagination108798
Date PublishedAUG
Type of ArticleArticle
ISSN1521-6616
Mots-cléschronic obstructive pulmonary disease, Cytokines, inflammation, Organic dust
Résumé

Inflammatory response in patients with COPD secondary to organic dust exposure (OD-COPD) is poorly understood. We therefore aimed to characterize inflammatory and immune profile from peripheral blood mononuclear cells (PBMC) in a group of patients with mild-to-moderate COPD secondary to organic dust exposure (OD-COPD), tobacco smoking (T-COPD), or both. We compared T, B and NK cells distribution and inflammatory (TNF-alpha, Il-113, IL-6), type 1 (IFN-gamma), type 2 (IL-4, IL-13) and type 3 (IL-17) immunity related cytokines at baseline, and after stimulation with LPS, flagellin and CD3/CD28 beads in all COPD groups. OD-COPD displayed significantly lower NK cells and CD8+ T cells compared with controls. After flagellin stimulation, T-COPD had significantly lower IL-13 levels than OD-COPD and controls (p < 0.05) whereas IFN-gamma tended to be lower in ODCOPD. All COPD groups displayed higher IL-113 and IL-17 than controls after CD3/CD28 stimulation. Inflammatory responses in OD-COPD were different from T-COPD. OD-COPD displayed higher levels of type 2 immunity related cytokines.

DOI10.1016/j.clim.2021.108798