Standardization of Chemotherapy and Individual Dosing of Platinum Compounds

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TitreStandardization of Chemotherapy and Individual Dosing of Platinum Compounds
Type de publicationJournal Article
Year of Publication2014
AuteursPuisset F, Schmitt A, Chatelut E
JournalANTICANCER RESEARCH
Volume34
Pagination465-470
Date PublishedJAN
Type of ArticleReview
ISSN0250-7005
Mots-clésChemotherapy, dosing, Platinum, Review
Résumé

Platinum compounds represent a pharmacological class essential for the treatment of certain types of cancer. Cisplatin, carboplatin, and oxaliplatin, share some physiochemical and pharmacological properties, in particular the ability to form DNA adducts. Carboplatin may be considered as an analog of cisplatin, but its pharmacokinetic properties, side-effects, and intrinsic activity are significantly different from those of cisplatin. The choice of one of these two compounds may be made rationally based on the individual patient's characteristics.