1,2,3-Triazole-gold(I)-triethylposphine derivatives active against resistant Gram-positive pathogens
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | 1,2,3-Triazole-gold(I)-triethylposphine derivatives active against resistant Gram-positive pathogens |
| Type de publication | Journal Article |
| Year of Publication | 2021 |
| Auteurs | Michaut M, Steffen A, Contreras J-M, Morice C, Schalk IJ, Plesiat P, Mislin GLA |
| Journal | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
| Volume | 40 |
| Pagination | 127879 |
| Date Published | MAY 15 |
| Type of Article | Article |
| ISSN | 0960-894X |
| Mots-clés | Antibiotic, Azide-alkyne Huisgen cycloaddition, Clostridium difficile, Enterococcus sp, Gold(I) complex, Staphylococcus sp |
| Résumé | Innovative organogold(I) antibacterial compounds were synthesized by click chemistry with triethylphosphinegold(I) azides and an alkyne derivative. The resulting organo-gold(I) compounds exhibit high levels of antibacterial activity against Gram-positive pathogens, with particularly low MICs against Clostridium difficile. |
| DOI | 10.1016/j.bmcl.2021.127879 |