Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

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TitreOccupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study
Type de publicationJournal Article
Year of Publication2015
AuteursCostas L., Infante-Rivard C., Zock J-P, Van Tongeren M., Boffetta P., Cusson A., Robles C., Casabonne D., Benavente Y., Becker N., Brennan P., Foretova L., Maynadie M., Staines A., Nieters A., Cocco P., de Sanjose S.
JournalBRITISH JOURNAL OF CANCER
Volume112
Pagination1251-1256
Date PublishedMAR 31
Type of ArticleArticle
ISSN0007-0920
Mots-clésAlkylphenols, chemicals, endocrine disruptors, leukaemia, lymphoma, pesticides, solvents
Résumé

Background: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. Methods: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. Results: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend = 0.02). Associations were observed among men, but not women. Conclusions: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.

DOI10.1038/bjc.2015.83