LIGHT CLEAVAGE OF SOME POTENTIAL LINKERS FOR DRUG CARRIERS
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | LIGHT CLEAVAGE OF SOME POTENTIAL LINKERS FOR DRUG CARRIERS |
| Type de publication | Journal Article |
| Year of Publication | 2016 |
| Auteurs | Alexandru T, Staicu A, Pascu A., Dinache A, Ben Abdeladhim A, Enescu M., Khatyr A., Pascu M.L |
| Journal | ROMANIAN REPORTS IN PHYSICS |
| Volume | 68 |
| Pagination | 684-692 |
| Type of Article | Article |
| ISSN | 1221-1451 |
| Mots-clés | Olefins, quenching rate constant, singlet oxygen generation |
| Résumé | The study of photocleavage of different substrates as potential linkers for drug carrier compounds is reported. The role of singlet oxygen and the kinetic rates implied in the photoreactions were determined. The study envisaged the use of two olefins: 7-(4-chlorophenyl)hept-6-enoic acid and 7-(ferrocene)hept-6-enoic acid as potential linkers for the controlled release of a specific drug, by singlet oxygen induced cleavage. The rate constants for quenching of the singlet oxygen by these olefins were determined. The photoproducts were analyzed by FTIR spectroscopy. |