Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties |
| Type de publication | Journal Article |
| Year of Publication | 2016 |
| Auteurs | Flack T, Constantin T, Penasse S, Dejeu J, Gennaro B, Jourdan M, Laguerre A, Pirrotta M, Monchaud D, Spinelli N, Defrancq E |
| Journal | CHEMISTRY-A EUROPEAN JOURNAL |
| Volume | 22 |
| Pagination | 1760-1767 |
| Date Published | JAN 26 |
| Type of Article | Article |
| ISSN | 0947-6539 |
| Mots-clés | cyclodecapeptide, DNAzyme, G-quadruplexes, G-quartets, supramolecular chemistry |
| Résumé | A water-soluble template-assembled synthetic G-quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase-type biocatalytic activities and improved quadruplex-interacting properties. Comparison of its DNAzyme-boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme-boosting agent. |
| DOI | 10.1002/chem.201504572 |