An oxidatively damaged G-quadruplex/hemin DNAzyme
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | An oxidatively damaged G-quadruplex/hemin DNAzyme |
| Type de publication | Journal Article |
| Year of Publication | 2020 |
| Auteurs | Wang J, Cheng M, Chen J, Ju H, Monchaud D, Mergny J-L, Zhou J |
| Journal | CHEMICAL COMMUNICATIONS |
| Volume | 56 |
| Pagination | 1839-1842 |
| Date Published | FEB 11 |
| Type of Article | Article |
| ISSN | 1359-7345 |
| Résumé | Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of DNAzyme deactivation, which originates from an interplay between decreased G-quadruplex stability, lower hemin affinity and a modification of the nature of hemin binding sites. |
| DOI | 10.1039/c9cc09237d |