Protective Effects of a Discontinuous Treatment with Alpha-Lipoic Acid in Obesity-Related Heart Failure with Preserved Ejection Fraction, in Rats
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Protective Effects of a Discontinuous Treatment with Alpha-Lipoic Acid in Obesity-Related Heart Failure with Preserved Ejection Fraction, in Rats |
| Type de publication | Journal Article |
| Year of Publication | 2020 |
| Auteurs | Pop C, Stefan M-G, Muntean D-M, Stoicescu L, Gal AFlorin, Kiss B, Morgovan C, Loghin F, Rochette L, Lauzier B, Mogosan C, Ghibu S |
| Journal | ANTIOXIDANTS |
| Volume | 9 |
| Pagination | 1073 |
| Date Published | NOV |
| Type of Article | Article |
| Mots-clés | alpha-lipoic acid, antioxidants, heart failure with preserved ejection fraction, Obesity, Oxidative stress |
| Résumé | {Obesity induces hemodynamic and humoral changes that are associated with functional and structural cardiac remodeling, which ultimately result in the development of heart failure (HF) with preserved ejection fraction (HFpEF). In recent years, pharmacological studies in patients with HFpEF were mostly unsatisfactory. In these conditions, alternative new therapeutic approaches are necessary. The aim of our study was (1) to assess the effects of obesity on heart function in an experimental model and (2) to evaluate the efficacy of an alpha-lipoic acid (ALA) antioxidant treatment. Sprague-Dawley rats (7 weeks old) were either included in the control group (n = 6) or subjected to abdominal aortic banding (AAB) and divided into three subgroups, depending on their diet: standard (AAB + SD |
| DOI | 10.3390/antiox9111073 |