Positive impact of autophagy in human breast cancer cells on local immunosurveillance
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Positive impact of autophagy in human breast cancer cells on local immunosurveillance |
| Type de publication | Journal Article |
| Year of Publication | 2016 |
| Auteurs | Ladoire S, Enot D, Senovilla L, Chaix M, Zitvogel L, Kroemer G |
| Journal | ONCOIMMUNOLOGY |
| Volume | 5 |
| Pagination | e1174801 |
| Type of Article | Article |
| ISSN | 2162-402X |
| Mots-clés | autophagy, Breast cancer, LC3, Lymphocytes, macrophages, Treg cells |
| Résumé | In human breast cancer cells, the presence of cytoplasmic dots positive for microtubule-associated proteins 1A/1B light chain 3B (LC3B) indicates enhanced autophagic flux and favorable prognosis. LC3B(+) puncta within malignant cells positively correlate with the intratumoral abundance of CD8(+) cytotoxic T lymphocytes, yet negatively correlate with the frequency of local FOXP3(+) regulatory T cells and CD68(+) tumor-associated macrophages, resulting in an improvement of CD8(+)/FOXP+ or CD8(+)/CD68(+) ratios. |
| DOI | 10.1080/2162402X.2016.1174801 |