Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats |
| Type de publication | Journal Article |
| Year of Publication | 2016 |
| Auteurs | Richert L, Baze A, Parmentier C, Gerets HHJ, Sison-Young R, Dorau M, Lovatt C, Czich A, Goldring C, B. Park K, Juhila S, Foster AJ, Williams DP |
| Journal | TOXICOLOGY LETTERS |
| Volume | 258 |
| Pagination | 207-215 |
| Date Published | SEP 6 |
| Type of Article | Article |
| ISSN | 0378-4274 |
| Mots-clés | Cryopreserved human hepatocytes, DILI, In vitro models, Monoculture and co-culture, Short term and long term exposure |
| Résumé | {Sixteen training compounds selected in the IMI MIP-DILI consortium, 12 drug-induced liver injury (DILI) positive compounds and 4 non-DILI compounds, were assessed in cryopreserved primary human hepatocytes. When a ten-fold safety margin threshold was applied, the non-DILI-compounds were correctly identified 2 h following a single exposure to pooled human hepatocytes (n = 13 donors) in suspension and 14-days following repeat dose exposure (3 treatments) to an established 3D-microtissue co-culture (3D-MT co-culture |
| DOI | 10.1016/j.toxlet.2016.06.1127 |