Synthesis of porphyrin-bis(polyazamacrocycle) triads via Suzuki coupling reaction

Suzuki-Miyaura cross-coupling reaction has been used for the synthesis of tricyclic architectures based on trans-A(2)B(2)-porphyrins and bisaminal-protected polyazamacrocycles which are linked directly or by a p-phenylene spacer. This modular approach allowed the synthesis of ligands with various substituted porphyrin macrocycles and bisaminal-protected tetraazamacrocycles possessing different cavity sizes. These molecules can be assembled into dimers using a DABCO linker. Deprotection of these compounds afforded porphyrin-bis(polyazamacrocycle) triads.