Retinal vascular fractal dimension and cerebral blood flow, a pilot study
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Retinal vascular fractal dimension and cerebral blood flow, a pilot study |
| Type de publication | Journal Article |
| Year of Publication | 2020 |
| Auteurs | Nadal J, Deverdun J, de Champfleur NMenjot, Carriere I, Creuzot-Garcher C, Delcourt C, Chiquet C, Kawasaki R, Villain M, Ritchie K, Le Bars E, Daien V |
| Journal | ACTA OPHTHALMOLOGICA |
| Volume | 98 |
| Pagination | E63-E71 |
| Date Published | FEB |
| Type of Article | Article |
| ISSN | 1755-375X |
| Mots-clés | arterial spin labelling, Cerebral blood flow, fractal dimension, fundus photographs, retinal vessels |
| Résumé | {Purpose Ocular and brain microcirculation share embryological and histological similarities. The retinal vascular fractal dimension (FD) is a marker of retinal vascular complexity of the vascular tree. The purpose of this study was to explore the relationship between cerebral blood flow (CBF), retinal vascular FD and other retinal vascular markers. Methods Cross-sectional analysis comprising 26 individuals >= 65 years old from the Cognitive REServe and Clinical ENDOphenotype (CRESCENDO) cohort of relative healthy older adults. Retinal vascular FD was measured from fundus photographs by using the semi-automated Singapore Eye Vessel Assessment (SIVA) software. CBF was estimated using a 2D pulsed ASL MRI sequence. Associations between blood flow and retinal parameters were analysed using linear regression models adjusted for age and sex. Results Cerebral blood flow was positively associated with venular FD (R-2 = 0.32 |
| DOI | 10.1111/aos.14232 |