Surface-promoted aggregation of amphiphilic quadruplex ligands drives their selectivity for alternative DNA structures
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Titre | Surface-promoted aggregation of amphiphilic quadruplex ligands drives their selectivity for alternative DNA structures |
Type de publication | Journal Article |
Year of Publication | 2015 |
Auteurs | Laguerre A, Chang Y, Pirrotta M, Desbois N, Gros CP, Lesniewska E, Monchaud D |
Journal | ORGANIC & BIOMOLECULAR CHEMISTRY |
Volume | 13 |
Pagination | 7034-7039 |
Type of Article | Article |
ISSN | 1477-0520 |
Résumé | Scientists are currently truly committed to enhance the specificity of chemotherapeutics that target DNA. To this end, sequence-specific drugs have progressively given way to structure-specific therapeutics. However, while numerous strategies have been implemented to design high-affinity candidates, strategies devoted to the design of high-selectivity ligands are still rare. Here we report on such an approach via the study of an amphiphilic compound, TEGPy, that self-assembles at a liquid/solid interface to provide nano-sized objects that are stable in water. The resulting aggregates, identified through atomic force microscopy measurements, were found to disassemble upon interaction with DNA in a structure-specific manner (quadruplex-versus duplex-DNA). Our results provide a fertile ground for devising new strategies aiming at concomitantly enhancing DNA structural specificity and the water-solubility of aggregationprone ligands. |
DOI | 10.1039/c5ob00692a |