Atrial Fibrillation Is Associated with a Marker of Endothelial Function and Oxidative Stress in Patients with Acute Myocardial Infarction
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Atrial Fibrillation Is Associated with a Marker of Endothelial Function and Oxidative Stress in Patients with Acute Myocardial Infarction |
| Type de publication | Journal Article |
| Year of Publication | 2015 |
| Auteurs | Stamboul K, Lorin J, Lorgis L, Guenancia C, Beer J-C, Touzery C, Rochette L, Vergely C, Cottin Y, Zeller M |
| Journal | PLOS ONE |
| Volume | 10 |
| Pagination | e0131439 |
| Date Published | JUL 9 |
| Type of Article | Article |
| ISSN | 1932-6203 |
| Résumé | {Background Atrial fibrillation (AF), whether silent or symptomatic, is a frequent and severe complication of acute myocardial infarction (AMI). Asymmetric dimethylarginine (ADMA), an endogenous eNOS inhibitor, is a risk factor for endothelial dysfunction. We addressed the relationship between ADMA plasma levels and AF occurrence in AMI. Methods 273 patients hospitalized for AMI were included. Continuous electrocardiographic monitoring (CEM) >= 48 hours was recorded and ADMA was measured by High Performance Liquid Chromatography on admission blood sample. Results The incidence of silent and symptomatic AF was 39(14%) and 29 (11%), respectively. AF patients were markedly older than patients without AF (approximate to 20 y). There was a trend towards higher ADMA levels in patients with symptomatic AF than in patients with silent AF or no AF (0.53 vs 0.49 and 0.49 mu mol/L, respectively |
| DOI | 10.1371/journal.pone.0131439 |