Phase 2 study of parsaclisib (INCB050465), a highly selective, next-generation PI3K delta inhibitor, in relapsed or refractory diffuse large B-cell lymphoma (CITADEL-202)

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TitrePhase 2 study of parsaclisib (INCB050465), a highly selective, next-generation PI3K delta inhibitor, in relapsed or refractory diffuse large B-cell lymphoma (CITADEL-202)
Type de publicationJournal Article
Year of Publication2021
AuteursColeman M, Belada D, Casasnovas R-O, Gressin R, Lee H-P, Mehta A, Munoz J, Verhoef G, Corrado C, DeMarini DJ, Zhao W, Li J, Fay K
JournalLEUKEMIA & LYMPHOMA
Volume62
Pagination368-376
Date PublishedJAN 28
Type of ArticleArticle
ISSN1042-8194
Mots-clésB-cell lymphoma, DLBCL, INCB050465, Inhibitor, non-Hodgkin lymphoma, parsaclisib, PI3K&\#948
Résumé

{Parsaclisib, a potent, highly selective, next-generation PI3K delta inhibitor, was evaluated as monotherapy in CITADEL-202 (NCT02998476), an open-label, multicenter, phase 2 study in patients with relapsed or refractory diffuse large B-cell lymphoma. Patients enrolled into 2 groups (A, Bruton tyrosine kinase [BTK] inhibitor naive

DOI10.1080/10428194.2020.1832660