Ultrasmall particles for Gd-MRI and Ga-68-PET dual imaging
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Ultrasmall particles for Gd-MRI and Ga-68-PET dual imaging |
| Type de publication | Journal Article |
| Year of Publication | 2015 |
| Auteurs | Truillet C, Bouziotis P, Tsoukalas C, Brugiere J, Martini M, Sancey L, Brichart T, Denat F, Boschetti F, Darbost U, Bonnamour I, Stellas D, Anagnostopoulos CD, Koutoulidis V, Moulopoulos LA, Perriat P, Lux F, Tillement O |
| Journal | CONTRAST MEDIA & MOLECULAR IMAGING |
| Volume | 10 |
| Pagination | 309-319 |
| Date Published | JUL-AUG |
| Type of Article | Article |
| ISSN | 1555-4309 |
| Mots-clés | multimodal imaging, Nanoparticles, PET/MRI |
| Résumé | Nanoparticles made of a polysiloxane matrix and surrounded by 1,4,7,10-tetraazacyclododecane-1-glutaric anhydride-4,7,10-triacetic acid (DOTAGA)[Gd3+] and 2,2'-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-1,4,7-t riazonane-1,4-diyl)diacetic acid) NODAGA[Ga-68(3+)] have been synthesized for positron emission tomography/magnetic resonance (PET/MRI) dual imaging. Characterizations were carried out in order to determine the nature of the ligands available for radiolabelling and to quantify them. High radiolabelling purity (>95%) after Ga-68 labelling was obtained. The MR and PET images demonstrate the possibility of using the nanoparticles for a combined PET/MR imaging scanner. The images show fast renal elimination of the nanoparticles after intravenous injection.Copyright (C) 2014 John Wiley & Sons, Ltd. |
| DOI | 10.1002/cmmi.1633 |