Phosphonium-Boronate Amino Acid Derivatives as Fluoride Pincers for F-18-Labelling
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Phosphonium-Boronate Amino Acid Derivatives as Fluoride Pincers for F-18-Labelling |
| Type de publication | Journal Article |
| Year of Publication | 2015 |
| Auteurs | Bernard J, Clemente G, Burke BP, Eymin M-J, Archibald SJ, Malacea-Kabbara R, Juge S |
| Journal | PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS |
| Volume | 190 |
| Pagination | 957-958 |
| Date Published | JUN 3 |
| Type of Article | Article; Proceedings Paper |
| ISSN | 1042-6507 |
| Mots-clés | a-amino acids, boronates, phosphonium salts, trifluoroborates, {[F-18]-labelling |
| Résumé | The synthesis of phosphonium-boronate amino acid derivatives was achieved by quaternization of o-boronatophenylphosphine with iodo-amino acid derivatives. Preliminary radiolabelling studies demonstrate the facile F-18-fluoride trapping and the high stability of the trifluoroborato products in aqueous conditions, making these new compounds very promising for molecular imaging of peptides and proteins using PET. |
| DOI | 10.1080/10426507.2014.979991 |