Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients

{To evaluate whether the risk of bone fragility on computed tomography (CT) (scanographic bone attenuation coefficient of the first lumbar vertebra (SBAC-L1)) is associated with the severity of spine structural involvement (mSASSS) in patients with ankylosing spondylitis (AS). This retrospective study included AS patients, followed from 2009 to 2017, who fulfilled the New York criteria and who underwent thoraco-abdomino-pelvic CT and radiography (spine, pelvis). The structural involvement was retained for mSASSS >= 2. The SBAC-L1 was measured in Hounsfield units (HU). A SBAC-L1 <= 145 HU was used to define patients at risk of vertebral fracture (VF). A total of 73 AS patients were included (mean age: 60.3 (+/- 10.7) years, 8 women (11%), mean disease duration: 24.6 years (+/- 13.9)). Sixty patients (82.2%) had a mSASSS >= 2 (mean score 20.7 (+/- 21.2)). The mean SBAC-L1 was 141.1 HU (+/- 45), 138.1 HU (+/- 44.8) and 154.8 HU (+/- 44.9) in the total, mSASSS >= 2 and mSASSS<2 populations, respectively. Patients with bone bridges had lower SBAC-L1 than mSASSS2 patients without ankylosis (p=0.02) and more often SBAC-L1 <= 145 HU (73% vs 41.9%