Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma |
| Type de publication | Journal Article |
| Year of Publication | 2020 |
| Auteurs | Depner M, Taft DHazard, Kirjavainen PV, Kalanetra KM, Karvonen AM, Peschel S, Schmausser-Hechfellner E, Roduit C, Frei R, Lauener R, Divaret-Chauveau A, Dalphin J-C, Riedler J, Roponen M, Kabesch M, Renz H, Pekkanen J, Farquharson FM, Louis P, Mills DA, von Mutius E, Ege MJ, Grp PASTUREStudy |
| Journal | NATURE MEDICINE |
| Volume | 26 |
| Pagination | 1766+ |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 1078-8956 |
| Résumé | {Growing up on a farm is associated with an asthma-protective effect, but the mechanisms underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural Environments (PASTURE) birth cohort, we modeled maturation using 16S rRNA sequence data of the human gut microbiome in infants from 2 to 12 months of age. The estimated microbiome age (EMA) in 12-month-old infants was associated with previous farm exposure (beta = 0.27 (0.12-0.43) |
| DOI | 10.1038/s41591-020-1095-x |