Should prenatal chromosomal microarray analysis be offered for isolated fetal growth restriction? A French multicenter study

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TitreShould prenatal chromosomal microarray analysis be offered for isolated fetal growth restriction? A French multicenter study
Type de publicationJournal Article
Year of Publication2021
AuteursMonier I, Receveur A, Houfflin-Debarge V, Goua V, Castaigne V, Jouannic J-M, Mousty E, Saliou A-H, Bouchghoul H, Rousseau T, Valat A-S, Groussolles M, Fuchs F, Benoist G, Degre S, Massardier J, Tsatsaris V, Kleinfinger P, Zeitlin J, Benachi A, Ctr FFederation
JournalAMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume225
Pagination676.e1-e15
Date PublishedDEC
Type of ArticleArticle
ISSN0002-9378
Mots-cléschromosomal microarray, copy number variants, fetal growth restriction, karyotype, Prenatal diagnosis
Résumé

BACKGROUND: Compared with standard karyotype, chromosomal microarray analysis improves the detection of genetic anomalies and is thus recommended in many prenatal indications. However, evidence is still lacking on the clinical utility of chromosomal microarray analysis in cases of isolated fetal growth restriction. OBJECTIVE: This study aimed to estimate the proportion of copy number variants detected by chromosomal microarray analysis and the incremental yield of chromosomal microarray analysis compared with karyotype in the detection of genetic abnormalities in fetuses with isolated fetal growth restriction. STUDY DESIGN: This retrospective study included all singleton fetuses diagnosed with fetal growth restriction and no structural ultrasound anomalies and referred to 13 French fetal medicine centers over 1 year in 2016. Fetal growth restriction was defined as an estimated fetal weight of
DOI10.1016/j.ajog.2021.05.035