Analyses of the local control of pulmonary Oligometastases after stereotactic body radiotherapy and the impact of local control on survival

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TitreAnalyses of the local control of pulmonary Oligometastases after stereotactic body radiotherapy and the impact of local control on survival
Type de publicationJournal Article
Year of Publication2020
AuteursYamamoto T, Niibe Y, Aoki M, Shintani T, Yamada K, Kobayashi M, Yamashita H, Ozaki M, Manabe Y, Onishi H, Yahara K, Nishikawa A, Katsui K, Oh R-J, Terahara A, Jingu K
JournalBMC CANCER
Volume20
Pagination997
Date PublishedOCT 14
Type of ArticleArticle
Mots-cléslocal control, Metastasis-directed therapy, Oligo-recurrence, Pulmonary oligometastases, Stereotactic body radiotherapy, Sync-oligometastases
Résumé

{BackgroundSuccessful local therapy for oligometastases may lead to longer survival. The purpose of this multicentre retrospective study was to investigate factors affecting the local control (LC) of pulmonary oligometastases treated by stereotactic body radiotherapy (SBRT) and to investigate the impact of LC on survival.MethodsThe inclusion criteria included 1 to 5 metastases, the primary lesion and other extrathoracic metastases were controlled before SBRT, and the biological effective dose (BED10) of the SBRT was 75Gy or more. The Cox proportional hazards model was used for analyses.ResultsData of 1378 patients with 1547 tumours from 68 institutions were analysed. The median follow-up period was 24.2months. The one-year, 3-year and 5-year LC rates were 92.1, 81.3 and 78.6%, respectively, and the 1-year, 3-year and 5-year overall survival rates were 90.1, 60.3 and 45.5%, respectively. Multivariate analysis for LC showed that increased maximum tumour diameter (p=0.011), type A dose calculation algorithm (p=0.005), shorter overall treatment time of SBRT (p=0.035) and colorectal primary origin (p<0.001 excluding oesophagus origin) were significantly associated with a lower LC rate. In the survival analysis, local failure (p<0.001), worse performance status (1 vs. 0

DOI10.1186/s12885-020-07514-9