Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes

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TitreChagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes
Type de publicationJournal Article
Year of Publication2021
AuteursMolina I, Marcolino MSoriano, Pires MCarvalho, Ramos LEmanuel Fe, Silva RTavares, Guimaraes-Junior MHenriques, de Oliveira IJose Ramos, de Carvalho RLima Rodri, Nunes AGabrielle, de Barros ALara Rodri, Scotton ALuiza Bahi, Madureira AAparecida, Farace BLopes, de Carvalho CAlcantara, Rodrigues FD'Athayde, Anschau F, Botoni FAntonio, Nascimento GFagundes, Duani H, Guimaraes HCerqueira, de Alvarenga JCoutinho, Moreira LBeltrami, Zandona LBarella, de Almeida LFonseca, Oliveira LMartins, Kopittke L, de Castro LCesar, Santos LElem Almei, Cabral MAlvares de, Ferreira MAngelica P, Sampaio Nda Cunha S, de Oliveira NRamos, Assaf PLedic, Lopes SJarjour Ta, Fereguetti TOliveira, Santos VBaldon dos, de Carvalho VEliel Bast, Ramires YCarlotto, Ribeiro ALuiz Pinho, Moscoso FAntonio Br, Moura R, Polanczyk CAnne, Nunes Mdo Carmo P
JournalSCIENTIFIC REPORTS
Volume11
Pagination20289
Date PublishedOCT 13
Type of ArticleArticle
ISSN2045-2322
Résumé

Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confirmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the 7018 patients who had confirmed COVID-19, 31 patients with CD and 124 matched controls were included (median age 72 (64-80) years-old, 44.5% were male). At baseline, heart failure (25.8% vs. 9.7%) and atrial fibrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p < 0.05). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). In-hospital management, outcomes and complications were similar between the groups. In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fibrillation and chronic heart failure compared with non-CD controls, with no differences in-hospital outcomes. The lower C-reactive protein levels in CD patients require further investigation.
DOI10.1038/s41598-021-96825-3