Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study
| Affiliation auteurs | !!!! Error affiliation !!!! |
| Titre | Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study |
| Type de publication | Journal Article |
| Year of Publication | 2022 |
| Auteurs | Rouze A, Lemaitre E, Martin-Loeches I, Povoa P, Diaz E, Nyga R, Torres A, Metzelard M, Cheyron Ddu, Lambiotte F, Tamion F, Labruyere M, Geronimi CBoulle, Luyt C-E, Nyunga M, Pouly O, Thille AW, Megarbane B, Saade A, Magira E, Llitjos J-F, Ioannidou I, Pierre A, Reignier J, Garot D, Kreitmann L, Baudel J-L, Voiriot G, Plantefeve G, Morawiec E, Asfar P, Boyer A, Mekontso-Dessap A, Makris D, Vinsonneau C, Floch P-E, Marois C, Ceccato A, Artigas A, Gaudet A, Nora D, Cornu M, Duhamel A, Labreuche J, Nseir S, Grp CVAPStudy |
| Journal | CRITICAL CARE |
| Volume | 26 |
| Pagination | 11 |
| Date Published | JAN 4 |
| Type of Article | Article |
| ISSN | 1364-8535 |
| Mots-clés | COVID-19, Intensive care unit, Invasive pulmonary aspergillosis, Mechanical ventilation, Severe influenza |
| Résumé | {Background: Recent multicenter studies identified COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large multicenter study has compared the incidence of IPA between COVID-19 and influenza patients. Objectives: To determine the incidence of putative IPA in critically ill SARS-CoV-2 patients, compared with influenza patients. Methods: This study was a planned ancillary analysis of the coVAPid multicenter retrospective European cohort. Consecutive adult patients requiring invasive mechanical ventilation for > 48 h for SARS-CoV-2 pneumonia or influenza pneumonia were included. The 28-day cumulative incidence of putative IPA, based on Blot definition, was the primary outcome. IPA incidence was estimated using the Kalbfleisch and Prentice method, considering extubation (dead or alive) within 28 days as competing event. Results: A total of 1047 patients were included (566 in the SARS-CoV-2 group and 481 in the influenza group). The incidence of putative IPA was lower in SARS-CoV-2 pneumonia group (14, 2.5%) than in influenza pneumonia group (29, 6%), adjusted cause-specific hazard ratio (cHR) 3.29 (95% CI 1.53-7.02 |
| DOI | 10.1186/s13054-021-03874-1 |